The Entourage Effect has been observed in various studies on plant medicine for decades and may account for the powerful health benefits experienced by CBD users. But what is the Entourage Effect, and why is it important? By learning how the Entourage Effect works, you will know how to harness its power in your daily CBD regimen.
The Entourage Effect: The Sum of the Parts
Cannabis sativa plants contain over 100 different cannabinoids, including cannabidiol (CBD) and tetrahydrocannabinol (THC). However, cannabis sativa extracts also contain a wealth of other chemical compounds including:
- Flavonoids – phytonutrients with powerful antioxidant properties.
- Fatty acids and natural plant waxes.
- Terpenes which are aromatic compounds that give cannabis products their flavour and offer potent health benefits in themselves.
A ground-breaking article by Ethan Russo published in the British Journal of Pharmacology reviews several studies on the effects of CBD and uses their pharmacology to explain their potential coaction in the human body. What Dr. Russo found was that a diverse cannabinoid and terpene profile may enhance the effects of cannabis products on the body.
He indicated that when certain phytochemicals found in cannabis are consumed together, they have a synergistic effect on one another which may amplify how the body responds to CBD.
Russo used the term the Entourage Effect to describe this process. The phrase was first used in relation to cannabis by Israeli biochemist Dr. Raphael Mechoulam, also called the “Father of Cannabis Research”.
If you take CBD oils or use creams with other phytocannabinoid elements, including terpenes, you’ll enjoy the benefits of CBD much faster than with CBD isolate alone.
How Does the Entourage Effect Work in the Body?
The Entourage Effect offers powerful potential therapeutic uses for CBD due to the way it works in the human body. CBD interacts with your endocannabinoid system (ECS) which is vital for regulating a range of biological functions such as mood, memory, appetite, and pain. The endocannabinoid system consists of three components:
- Endocannabinoids: Chemical messengers naturally produced by your body.
- Receptors: Located on the surface of cells throughout the central nervous system and immune system – these receptors respond to endocannabinoids and transmit chemical messages through the body.
- Enzymes: Function as an off switch for the receptors to stop proteins and hormones activated by the endocannabinoids.
CBD does not directly affect your ECS; rather, it interacts with the receptors to change how they respond to your body’s endocannabinoids. The variety of cannabinoids and terpenes found in full-spectrum CBD products enhance and augment this process through a range of mechanisms.
A study by Phytomedicine on phytopharmaceuticals suggests that there are four proposed mechanisms for synergy that apply to cannabis products including:
- Multiple target effects, whereby the combination of compounds allows the product to elicit therapeutic benefits on a range of systems.
- Pharmacokinetic effects that influence the bioavailability of the CBD product.
- Chemical interaction which may disrupt antibiotic resistance.
- Combatting the adverse effects of THC, such as psychoactivity and memory-loss.
These mechanisms, combined with further research on the vast range of other cannabinoids present in CBD oil, present many versatile therapeutic uses for CBD in the health and wellness industry.
Full-Spectrum or CBD Isolate: Is CBD Still Effective on Its Own?
Although many users prefer the synergistic effect of full-spectrum CBD, there are benefits to using CBD isolate. It is reassuring to know exactly which cannabinoid you are ingesting and isolate allows you to more precisely control your dosage.
Isolate is also suitable for users who may need to undergo regular drug testing as part of their occupation, as most standard cannabis drug tests only detect levels of THC. Other users may find that they have a sensitivity to THC or certain terpenes which makes CBD isolate the perfect choice for their wellness regimen.
For people who want the benefits of full-spectrum CBD without the complications of THC, broad-spectrum CBD products offer a happy compromise. Broad-spectrum CBD products undergo a further purification process that eliminates THC, but leaves the remaining cannabinoids and terpenes.
While you won’t enjoy any interaction between THC and CBD, you will experience a limited synergistic effect between the remaining cannabinoids and terpenes.
Is CBD Oil with THC Legal?
Full-spectrum CBD products derived from industrial hemp naturally contain less than 0.2% THC, which is below the legal limit in Europe. However, even these trace amounts of THC are enough to encourage the Entourage Effect, but these will not get you high.
To experience the Entourage Effect for yourself, try Canzon’s range of full-spectrum CBD products. If you want to avoid THC completely, enjoy a sense of calm and enhance your wellness routine with broad-spectrum CBD oil or isolate. No matter which type of CBD product you choose, you can look forward to better health, naturally.